HCID 86639325, compound → HCID 67102240, compound

Participants

Reaction Steps

A solution of methyl-2-(acetylacetamido)-3-methoxy-6-(trifluoromethyl)benzoate in 2N NaOH was heated to reflux for 4-5 h. The reaction mixture was cooled and pH was adjusted to 2. The product was extracted in ethyl acetate. The ethyl acetate extracts were combined, washed with brine and dried over sodium sulfate. Filtered, evaporated and residue was triturated with hexane. The solid was collected by filtration and dried under vacuum to provide product as light brown solid in 85% yield. ES/MS m/z 236.0 (MH+).

Provenance & Evidence