Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | HCID 59199248 | HCID 59199248 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178490585 | HCID 178490585 | 70% |
Reaction Steps
A mixture of 2-amino-3-methoxy-6-(trifluoromethyl)benzaldehyde (1 eq) (obtained from step 7) and urea (15 equiv.) was heated to 175° C. with vigorous stirring for 2 h. The reaction was cooled to room temperature and water was added. The solid was collected by filtration. Air-dried to give 8-methoxy-5-(trifluoromethyl) quinazolin-2-ol as yellow solid in 70% yield. ES/MS m/z 245.0 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07932262B2 |
|---|
| Source dataset | uspto-grants-2011_04 |
|---|
| ORD ID | ord-5bae4f2db19140bb9857811c82f1b4bc |
|---|
| Source note | uspto-grants-2011_04 |
|---|
