HCID 57480126, compound → HCID 59199315, compound

HRID 2079687Notes

Reaction equation

HRID 2079687 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:14]([F:17])([F:16])[F:15])=[C:7]2[C:12]=1[N:11]=[C:10](O)[N:9]=[CH:8]2.P(O[Cl:22])(=O)=O>>[Cl:22][C:10]1[N:9]=[CH:8][C:7]2[C:12](=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[C:14]([F:17])([F:16])[F:15])[N:11]=1

Participants

3

Reactant 2

HCID 57480126HCID 57480126, compoundHCID 178490585HCID 178490585, compound

Product 1

HCID 59199315HCID 59199315, compoundYield 70%

Procedure

The crude 8-methoxy-5-(trifluoromethyl) quinazolin-2-ol was heated in neat phosphooxychloride (POCl3) at 110° C. for 2 h. The resulted mixture was cooled to room temperature and concentrated in vacuo to nearly dryness. Ice water was added and precipitate was filtered, washed and dried to provide 2-chloro-8-methoxy-5-(trifluoromethyl) quinazoline as a light pink solid in 70% yield. ES/MS m/z 263.0 (MH+).

Workup

  1. concentrationconcentrated in vacuo to nearly dryness
  2. additionIce water was added
  3. filtrationprecipitate was filtered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-2ff1cc8487b242a1921ea26c4001b44d
Source dataset
uspto-grants-2011_04
Patent number
US07932262B2

Reaction notes

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