Ethyl Acetate → HCID 59199268, compound

Participants

Reaction Steps

To the solution of N-(2-(pyrrolidin-1-yl)ethyl)-3-(trifluoromethyl)pyridin-2-amine (1030 mg, 4 mmole) in 10 ml of acetic acid, bromine (203 ul, 4 mmole) was added. The reaction solution was stirred at room temperature for 1.5 hr and then concentrated under vacuo to give an orange solid. The crude product was dissolved with 40 ml of ethyl acetate to give a yellow milky mixture that was then filtered and washed to give an ivory powder as HBr salt of 5-bromo-N-(2-(pyrrolidin-1-yl)ethyl)-3-(trifluoromethyl)pyridin-2-amine (963 mg). ES/MS m/z 335.9, 337.9 (MH+).

Provenance & Evidence