HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfanilamide → HCID 67102425, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfanilamide | HCID 5333 | — |
| Reactant | 2-Chloro-8-[(6-fluoro-3-pyridinyl)oxy]quinazoline | HCID 86639327 | — |
| Reactant | HCID 86639328 | HCID 86639328 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 67102425 | HCID 67102425 | 61% |
Reaction Steps
To a 0.13 M solution of the 2-chloro-8-(6-fluoropyridin-3-yloxy)quinazoline and 2-bromo-8-(6-fluoropyridin-3-yloxy)quinazoline mixture in i-PrOH was added sulfanilamide (1.0 eq.) and the solution was heated to refluxed for 12 hr. Cooled to room temperature and the precipitate was filtered off and washed with i-PrOH to give the desired product in 61% yield. The solid was 96% pure by HPLC. ES/MS m/z 412.0 (MH+) for 595644-4-(8-(6-fluoropyridin-3-yloxy)quinazolin-2-ylamino)benzenesulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932262B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-bec4fec69f844529a7a45dd020012dc5 |
| Source note | uspto-grants-2011_04 |