Dichloromethane → 4-[4-(4-Ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl]piperazin-2-one
Reaction equation
[B:29]([Br:30])([Br:31])[Br:32].[CH2:1]([CH3:2])[c:3]1[cH:4][c:5]([O:27][CH3:28])[c:6]([O:7][c:8]2[c:9]([F:23])[cH:10][c:11]([C:12](=[O:13])[N:14]3[CH2:15][C:16](=[O:20])[NH:17][CH2:18][CH2:19]3)[cH:21][cH:22]2)[cH:24][c:25]1[F:26].[Cl:33][CH2:34][Cl:35]>>[CH2:1]([CH3:2])[c:3]1[cH:4][c:5]([OH:27])[c:6]([O:7][c:8]2[c:9]([F:23])[cH:10][c:11]([C:12](=[O:13])[N:14]3[CH2:15][C:16](=[O:20])[NH:17][CH2:18][CH2:19]3)[cH:21][cH:22]2)[cH:24][c:25]1[F:26]Participants
4
Sources & evidence
- ORD record
- ord-a206316d51464149b88c925b2cc33c15
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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