Trifluoroacetic acid → HCID 59784095, compound

Participants

Reaction Steps

Compound 4 (15.50 g, 26.2 mmol) is BOC-deprotected using TFA (97 mL, 1.31 mol) in CH2Cl2 (500 mL) under the same conditions as for step 2. After workup, the desired free amine 5 is obtained as an off-white foam (12.57 g, 97% yield): 1H NMR δ (CDCl3) 7.28-7.42 (m, 5H), 7.03-7.19 (m, 4H), 6.07-6.35 (br m, 1H), 5.09-5.27 (br m, 3 H), 3.68-4.81 (br m, 3H), 2.66-3.53 (br m, 6H), 1.45-2.04 (br m, 8H), 0.74-1.00 (br m, 1H); LCMS (APCl+) 493.7 (MH+, 100%).

Provenance & Evidence