Trifluoroacetic acid → HCID 66875521, compound

Participants

Reaction Steps

A solution of tert-butyl 6-[(2-napthylsulfonyl)amino]-3-azabicyclo[3.1.0]hexane-3-carboxylate (27.50 g, 68.43 mmol) in 20% TFA in DCM (300 ml) was stirred at r.t. for 2 h. The reaction mixture was concentrated in vacuo and then DCM (100 ml) was added and removed in vacuo three times to remove excess TFA giving the title compound as the trifluoroacetate salt (crude yield=34.0 g). This product was used in the next step without further purification. 1H NMR (400 MHz, d6-DMSO) δ: 1.86 (2H, s), 2.20 (1H, m), 3.22 (4H, m), 7.70-7.75 (2H, m), 7.83 (1H, dd), 8.08 (1H, d), 8.18-8.23 (3H, m), 8.33 (1H, br s), 8.48 (1H, s), 9.20 (1H, br s).

Provenance & Evidence