Hydrochloric Acid → HCID 59367641, compound

Participants

Reaction Steps

Ethyl 2-(6-morpholin-4-yl-3-azabicyclo[3.1.0]hex-3-yl)pyrimidine-5-carboxylate (16 mg, 0.05 mmol) was dissolved in THF (1 ml) and a solution of 6M NaOH in water (0.5 ml) was added. The reaction was stirred at r.t. for 18 h. More 6M NaOH (0.5 ml) was added and the reaction stirred for a further 24 h. The reaction mixture was evaporated to leave only the aqueous portion, which was acidified to pH˜1 using 10% aq. HCl, then evaporated to dryness and used in the next step without further purification. LCMS purity 100%, m/z 291 [M+H]+.

Provenance & Evidence