Hydrochloric Acid → HCID 59367574, compound

Participants

Reaction Steps

N-(1-Isobutoxyethoxy) 2-(6-morpholin-4-yl-3-aza-bicyclo[3.1.0]hex-3-yl)pyrimidine-5-carboxamide (10 mg, 0.02 mmol) was dissolved in DCM (2 ml) and treated with 4M HCl in dioxane (0.4 ml, 0.1 mmol). The resultant mixture was stirred at r.t. for 30 min, then evaporated under reduced pressure and azeotroped with MeOH (3×5 ml) to give the title compound as a white solid (2.3 mg, 40%). LCMS purity 90%, m/z 306 [M+H]+, 1H NMR (300 MHz, CD3OD) δ: 2.49 (2H, br s), 2.85 (1H, br s), 3.55-3.87 (8H, m), 4.10 (4H, m), 8.72 (2H, s).

Provenance & Evidence