HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl ketone → 2-Ethyl-2-(1-pyrrolidinyl)butanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl ketone | HCID 7288 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-Methyl-2-(pyrrolidin-1-yl)propanenitrile | HCID 12570647 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Ethyl-2-(1-pyrrolidinyl)butanenitrile | HCID 43802763 | 100% |
Reaction Steps
The title compound (8.8 g, 100%) was prepared from pyrrolidine (8.96 ml, 0.107 mol), 3-pentanone (8.61 g, 0.1 mol) and potassium cyanide (6.51 g, 0.1 mol) in water (50 ml) in a similar manner to that described in D4. 1H NMR (CDCl3) δ: 0.95 (6H, t, J=7.6 Hz), 1.67-1.90 (8H, m), 2.67-2.72 (4H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745642B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-75a495d4416547e6947399e69d4fc15d |
| Source note | uspto-grants-2010_06 |