Trifluoroacetic acid methylene chloride → HCID 66875636, compound

HRID 2079802Notes

Reaction equation

HRID 2079802 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:7]=[N:8][C:9]([NH:12][CH:13]2[CH:18]3[CH:14]2[CH2:15][N:16](C(OC(C)(C)C)=O)[CH2:17]3)=[N:10][CH:11]=1)=[O:5])[CH3:2].[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27].C(Cl)Cl>>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[CH:14]12[CH:13]([NH:12][C:9]3[N:8]=[CH:7][C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])=[CH:11][N:10]=3)[CH:18]1[CH2:17][NH:16][CH2:15]2

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 66876537HCID 66876537, compound

Product 1

HCID 66875636HCID 66875636, compound

Procedure

A solution of tert-butyl 6-{[5-(ethoxycarbonyl)pyrimidin-2-yl]amino}-3-azabicyclo[3.1.0]hexane-3-carboxylate (0.15 g) was allowed to stand in 20% TFA/DCM (10 ml) at r.t. for 1 h. The reaction mixture was concentrated to dryness giving the title product as the TFA salt (0.17 g). LCMS purity 76%, m/z 249 [M+H]+. The product was used in the next stage without purification.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-004e5cb5e2c046f295925fb7e762df20
Source dataset
uspto-grants-2011_04
Patent number
US07932246B2

Reaction notes

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