Hydrochloric Acid → HCID 59367663, compound

Participants

Reaction Steps

1M NaOH (10 ml) was added to a solution of ethyl 2-{3-[(2-naphthylsulfonyl)amino]azetidin-1-yl}pyrimidine-5-carboxylate (347 mg, 0.84 mmol) in THF (10 ml) and MeOH (2 ml) and the reaction stirred at r.t. overnight. The reaction mixture was acidified to pH˜2 (2M HCl) before adjusting to pH˜7 with sat. NaHCO3 giving a white precipitate. The reaction was cooled to 0° C. and the precipitate isolated by filtration affording the title compound as a white solid (303 mg, 94%). LCMS purity 97%, m/z 385 [M+H]+.

Provenance & Evidence