Triethylamine → HCID 59367688, compound

Participants

Reaction Steps

EDCl (90 mg, 0.47 mmol) was added to a solution of 2-{3-[(2-naphthylsulfonyl)amino]azetidin-1-yl}pyrimidine-5-carboxylic acid (150 mg, 0.39 mmol) in DCM (10 ml) and THF (10 ml) at r.t. under N2. Et3N (0.14 ml, 1.02 mmol), HOBt (63 mg, 0.47 mmol) and O-(tetrahydro-pyran-2-yl)-hydroxylamine (55 mg, 0.47 mmol) were added and the reaction stirred at r.t. overnight. The reaction mixture was concentrated in vacuo giving a colourless oil which was dissolved in DCM (20 ml), washed with water (3×20 ml), dried (Na2SO4) and concentrated in vacuo to give the title compound as a white solid (162 mg, 86%). LCMS purity 93%, m/z 484 [M+H]+.

Provenance & Evidence