Hydrochloric Acid → HCID 66875593, compound

Participants

Reaction Steps

To ethyl 2-[5-(tert-butoxycarbonyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]pyridine-5-carboxylate (1.429 g, 3.92 mmol) was added 4M HCl in dioxane (10 ml, 40 mmol). The mixture was stirred for 2 h, then Et2O (50 ml) was added. The product was collected by filtration and washed with further Et2O (50 ml) to yield the title compound (1.19 g, quant.). 1H NMR (300 MHz, d6-DMSO) δ: 9.95 (1H, br s), 9.84 (1H, br s), 8.44 (1H, d, J=1.8 Hz), 8.20 (1H, dd, J=2.1, 9.3 Hz), 7.01 (1H, d, J=9.3 Hz), 4.31 (2H, q, J=7.2 Hz), 3.0-4.05 (10H, m), 1.31 (3H, t, J=7.2 Hz).

Provenance & Evidence