HCID 44192411, compound → HCID 44192410, compound

HRID 2079839Notes

Reaction equation

HRID 2079839 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]([C:11](=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.[CH3:17][C:18](C)(C)[C:19](C1C2C(=NC=C(C3C=CC4NC(=O)CSC=4C=3)N=2)NC=1)=O.Br[C:44]1[CH:45]=[CH:46][C:47]2[O:52][C:51]([CH3:54])([CH3:53])[C:50](=[O:55])[NH:49][C:48]=2[CH:56]=1>>[CH3:53][C:51]1([CH3:54])[C:50](=[O:55])[NH:49][C:48]2[CH:56]=[C:44]([C:2]3[N:3]=[C:4]4[C:10]([C:11]([C:12]5([CH3:15])[CH2:14][CH2:19][CH2:18][CH2:17][CH2:13]5)=[O:16])=[CH:9][NH:8][C:5]4=[N:6][CH:7]=3)[CH:45]=[CH:46][C:47]=2[O:52]1

Participants

4

Reactant 3

HCID 44192411HCID 44192411, compoundHCID 578292181-(2-Bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethylpropan-1-oneHCID 578292256-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one

Product 1

HCID 44192410HCID 44192410, compound

Procedure

Substituting (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-(1-methyl-cyclohexyl)-methanone for 1-(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-2,2-dimethyl-propan-1-one. MP=>300 C., (M+H)+=419. 7-[7-(2,2-Dimethyl-propionyl)-5H-pyrrolo[2,3-b]pyrazin-2-yl]-4H-benzo[1,4]thiazin-3-one. Substituting 7-bromo-4H-benzo[1,4]thiazin-3-one for 6-bromo-2,2-dimethyl-4H-benzo[1,4]oxazin-3-one. MP=>300 C., (M+H)+=367.

Sources & evidence

ORD record
ord-10d836d3a4b6457c8973e9a0890d345b
Source dataset
uspto-grants-2011_04
Patent number
US07932254B2

Reaction notes

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