HCID 57695554, compound → HCID 57695589, compound

HRID 2079863Notes

Reaction equation

HRID 2079863 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:12]([C:23]2[CH:28]=[C:27]([CH:29]([CH3:31])[CH3:30])[CH:26]=[CH:25][C:24]=2[O:32][CH3:33])=[CH:11][C:10]=1[C:34]1[N:38]([CH:39]2[CH2:44][CH2:43]C[NH:41][CH2:40]2)[N:37]=[N:36][N:35]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(N1CCC(N2C(C3C=C(C4C=C(C(C)C)C=CC=4OC)C(OCC4C=CC=CC=4)=CC=3OCC3C=CC=CC=3)=NN=N2)C1)=O)(C)(C)C>>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:12]([C:23]2[CH:28]=[C:27]([CH:29]([CH3:31])[CH3:30])[CH:26]=[CH:25][C:24]=2[O:32][CH3:33])=[CH:11][C:10]=1[C:34]1[N:38]([CH:39]2[CH2:44][CH2:43][NH:41][CH2:40]2)[N:37]=[N:36][N:35]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 57695554HCID 57695554, compoundHCID 67103120HCID 67103120, compound

Product 1

HCID 57695589HCID 57695589, compound

Procedure

This product was prepared using the same procedure as for compound 35 except 3-[5-(4,6-bis-benzyloxy-5′-isopropyl-2′-methoxy-biphenyl-3-yl)-tetrazol-1-yl]-pyrrolidine-1-carboxylic tert-butyl ester was used as starting material. M.p.: 85-87° C.; 400 MHz 1H NMR (DMSO-d6) δ: 7.34-7.10 (m, 15H), 6.96 (d, J=7.6 Hz, 1H), 5.26 (s, 2H), 5.21 (s, 2H), 4.79 (br s, 1H), 3.67 (s, 3H), 3.01 (m, 2H), 2.81 (m, 2H), 2.07 (m, 2H), 1.92 (m, 1H), 1.16 (d, J=6.0 Hz, 6H); LCMS: 576 [M+H].

Workup

  1. customThis product was prepared

Sources & evidence

ORD record
ord-b266a7f01d7444b6af92d8dcfca6e054
Source dataset
uspto-grants-2011_04
Patent number
US07932279B2

Reaction notes

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