Cesium fluoride → HCID 67101807, compound

Participants

Reaction Conditions

Reaction Steps

Heat a mixture of N-[3-(4-Chloro-5-cyano-thiophen-2-yl)-1-isopropyl-1H-indol-6-yl]-methanesulfonamide (Example 118) (0.15 g, 0.381 mmol) and CsF (0.324 g, 2.13 mmol) in DMSO (5 ml) at 150° C. for 6 hours under N2. Cool the mixture to 21° C. and dilute with EtOAc. Wash the mixture with water, brine, and dried over MgSO4. Filter the material and concentrate to dryness. Purify the crude product by reverse phase chromatography to yield 5 mg of the title compound. MS: 378.0 (MH+)

Provenance & Evidence