HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2079941Generated: October 30, 2026
Sulfuric Acid → Methyl 2-amino-6-chloronicotinate
https://huagongshe.com/reaction/2079941
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Amino-6-chloronicotinic acid | HCID 12263992 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-amino-6-chloronicotinate | HCID 57415887 | 68% |
Reaction Steps
To methanol (50 mL) were added concentrated sulfuric acid (25 mL) and 2-amino-6-chloro-nicotinic acid (4.3 g, 25 mmol) described in Preparation Example A-1 (or A-4) on an ice bath, which was stirred at 70° C. for 5 hours. After cooling, an aqueous solution of sodium bicarbonate (90 g) was added to neutralize. The resulting solid was filtered to obtain the title compound (3.2 g, 17 mmol, 68%) as a light brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932272B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-c74a1e8aeec440cfa5b5beaeea791d02 |
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| Source note | uspto-grants-2011_04 |
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