反应详情

温度

105 °C

To a solution of 4-amino-3-iodo-benzoic acid methyl ester (11.30 g, 40.77 mmol) in toluene (300 mL) were added tributyl(1-ethoxyvinyl)tin (16.5 mL, 48.9 mmol) and tetrakis(triphenylphosphine)palladium(0) (9422 mg, 8.154 mmol) under nitrogen atmosphere, and the solution was stirred at 105° C. for 7 hours. After cooling to room temperature, water was added, the mixture was extracted with ethyl acetate-tetrahydrofuran, the organic layer was washed with water, and then, evaporated. The residue was dissolved in 280 mL of tetrahydrofuran, 2N hydrochloric acid (80 mL) was added thereto, followed by stirring for 3 hours at room temperature. The reaction mixture was cooled on an ice bath, an aqueous solution of 2N sodium hydroxide (80 mL) was added, an aqueous solution of saturated sodium bicarbonate was further added, and the solution was extracted with ethyl acetate. An aqueous solution of 10% potassium fluoride was added to the organic layer, and the solution was stirred for 3 hours at room temperature. The organic layer was separated, washed with brine, then evaporated, the residue was purified by silica gel column chromatography (hexane-ethyl acetate), and title compound (6.42 g, 33.2 mmol, 81.4%) was obtained.

1. temperatureAfter cooling to room temperature
2. extractionthe mixture was extracted with ethyl acetate-tetrahydrofuran
3. washthe organic layer was washed with water
4. customevaporated
5. dissolutionThe residue was dissolved in 280 mL of tetrahydrofuran
6. addition2N hydrochloric acid (80 mL) was added
7. stirringby stirring for 3 hours at room temperature
8. temperatureThe reaction mixture was cooled on an ice bath
9. additionan aqueous solution of 2N sodium hydroxide (80 mL) was added
10. additionan aqueous solution of saturated sodium bicarbonate was further added
11. extractionthe solution was extracted with ethyl acetate
12. additionAn aqueous solution of 10% potassium fluoride was added to the organic layer
13. stirringthe solution was stirred for 3 hours at room temperature
14. customThe organic layer was separated
15. washwashed with brine
16. customevaporated
17. customthe residue was purified by silica gel column chromatography (hexane-ethyl acetate)