Water → HCID 23130552, compound

HRID 2080020Notes

Reaction equation

HRID 2080020 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[S:8][CH:9]=[CH:10][C:5]2=[CH:4][C:3]=1[C:11]#N.[OH-:13].[Na+].[OH2:15]>S(=O)(=O)(O)O>[NH2:1][C:2]1[N:7]=[C:6]2[S:8][CH:9]=[CH:10][C:5]2=[CH:4][C:3]=1[C:11]([OH:15])=[O:13]

Participants

5

Reactant 3

HCID 962WaterHCID 14798Sodium HydroxideHCID 23130750HCID 23130750, compound

Product 1

HCID 23130552HCID 23130552, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

6-Amino-thieno[2,3-b]pyridine-5-carbonitrile described in Preparation Example T-5 (104 mg, 0.594 mmol) was dissolved in a mixture solution of water (1.5 mL) and sulfuric acid (1.5 mL), and the solution was stirred for 3 hours under reflux. An aqueous solution of 5N sodium hydroxide was added to the reaction solution at 0° C., to neutralize the solution. The precipitated solid was filtered, and title compound (65 mg, 0.33 mmol, 56%) was obtained as a pale yellow solid.

Workup

  1. temperatureunder reflux
  2. filtrationThe precipitated solid was filtered

Sources & evidence

ORD record
ord-9b69d7fcf8af49068a9ea0ff3550728e
Source dataset
uspto-grants-2011_04
Patent number
US07932272B2

Reaction notes

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