Water → HCID 23130496, compound

Participants

Reaction Conditions

Reaction Steps

5-Nitro-thiophene-2-carbonitrile(1.5 g, 9.7 mmol), phenol (1.8 g, 19.4 mmol) and potassium carbonate(4.0 g, 29.1 mmol) were suspended in dimethylsulfoxide (20 mL), and the mixture was stirred for 50 minutes at 60° C., followed by further stirring overnight at room temperature. Water and ethyl acetate were added to the reaction mixture, which was then partitioned, the organic layer was washed 4 times with water, then, NH silica gel was added to the organic layer, the solvent was evaporated in vacuo for adsorption, purification was carried out by NH silica gel column chromatography (hexane, then hexane:ethyl acetate=20:1, then 10:1), and the title compound (1.4 g, 7.0 mmol, 72.1%) was obtained as a pale yellow oil.

Provenance & Evidence