反应详情

5-Oxo-2-phenoxythiocarbonyl-2,5-dihydro-isoxazole-4-carboxylic acid ethyl ester described in Preparation Example 113 (500 mg, 2.01 mmol) was dissolved in acetone (500 mL), and the solution was irradiated with light (300 nm) for 30 minutes at room temperature. The reaction solution was evaporated in vacuo, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1), and the title compound (384 mg, 1.54 mmol, 90%) was obtained as a pale yellow oil.

1. customthe solution was irradiated with light (300 nm) for 30 minutes at room temperature
2. customThe reaction solution was evaporated in vacuo
3. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)