HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2080261Generated: October 29, 2026
3-Bromodiphenyl ether → HCID 23130742, compound
https://huagongshe.com/reaction/2080261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-Bromodiphenyl ether | HCID 96165 | — |
| Reactant | 1-(Quinolin-6-yl)ethan-1-one | HCID 258559 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Catalyst | Ferrocene-1,1'-bis-(diphenylphosphine) | HCID 635956 | — |
| Catalyst | (1E,4E)-1,5-diphenylpenta-1,4-dien-3-one; palladium | HCID 6505921 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23130742 | HCID 23130742 | 19% |
Reaction Steps
According to an analogous method to Example W-3, 1-quinolin-6-yl-ethanone described in Preparation Example 131 (171 mg, 1 mmol), 1-phenoxy-3-bromobenzene (274 mg, 1.1 mmol), bis(dibenzylideneacetone)palladium (10 mg, 0.0187 mmol), 1,1′-bis(diphenylphosphino)ferrocene (12.5 mg, 0.0225 mmol), potassium tert-butoxide (236 mg, 2.1 mmol) and tetrahydrofuran (15 mL) were stirred at 70° C. for 6 hours under nitrogen atmosphere, and the title compound (64 mg, 0.189 mmol, 19%) was obtained as a pale yellow oily substance.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07932272B2 |
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| Source dataset | uspto-grants-2011_04 |
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| ORD ID | ord-e5a9dfac1ea547a1b5f31fa98c2193dd |
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| Source note | uspto-grants-2011_04 |
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