6-Hydroxyquinoline → HCID 23130717, compound

Participants

Reaction Steps

To a solution of quinoline-6-ol (37 mg, 0.25 mmol), 1-benzyloxy-4-chloromethyl-benzene (70 mg, 0.30 mmol) in dimethylsulfoxide (2.5 mL) was added potassium tert-butoxide (43 mg, 0.38 mmol) under nitrogen atmosphere, and the solution was stirred for 13 hours at room temperature. This reaction solution was purified by thin layer silica gel chromatography (hexane:ethyl acetate=1:1), and the title compound (74 mg, 0.217 mmol, 86%) was obtained as a pale yellow solid.

Provenance & Evidence