反应详情

To a solution of (4butyl-3-methyl-phenyl)-quinoline-6-yl-methanol described in Preparation Example Z+-1 (152 mg, 0.50 mmol) in chloroform (1.0 mL) was added active manganese dioxide (510 mg, 5.0 mmol), and the solution was stirred at room temperature for 5 hours. Manganese dioxide was removed by filtering through Celite pad, the filtrate was concentrated, the residue was purified by silica gel column chromatography (hexane:ethyl acetate), and the title compound (56 mg, 37%) was obtained as a pale yellow oil.

1. customManganese dioxide was removed
2. filtrationby filtering through Celite pad
3. concentrationthe filtrate was concentrated
4. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate)