HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 2,6-dichloropyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,6-Dichloronicotinic acid | HCID 854047 | — |
| Product | Methyl 2,6-dichloropyridine-3-carboxylate | HCID 11106516 | — |
Reaction Steps
To a solution of 2,6-dichloronicotinic acid (50 g, 0.26 mol) in methanol (250 mL) was added thionyl chloride (22.7 mL, 0.312 mol) slowly. The mixture was refluxed for 4 hours and concentrated to give methyl 2,6-dichloronicotinate as a white solid in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932270B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-f0e23be35fc94c6190844126432f4e91 |
| Source note | uspto-grants-2011_04 |