HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Hydroxybenzotriazole → HCID 57542266, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | (5R)-5-(Aminomethyl)pyrrolidin-2-one | HCID 22865792 | — |
| Reactant | 6-(2-Cyanophenyl)-2-(3-fluorophenethylamino)nicotinic acid | HCID 57542304 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 57542266 | HCID 57542266 | 67% |
Reaction Steps
To a mixture of 6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinic acid (110 mg, 0.30 mmol), (R)-5-(aminomethyl)pyrrolidin-2-one (52 mg, 0.46 mmol), HOBT (62 mg, 0.46 mmol), and HBTU (174 mg, 0.46 mg) in RB flask was added DMF and the mixture was stirred at r.t. for 1 h. LC/MS indicated the reaction was complete and the mixture was filtered and purified on RP-HPLC using a mixture of acetonitrile and water to give (R)-6-(2-cyanophenyl)-2-(3-fluorophenethylamino)-N-((5-oxopyrrolidin-2-yl)methyl)nicotinamide (91.6 mg, 67%). LRMS (M+H+) m/z 458.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07932270B2 |
| Source dataset | uspto-grants-2011_04 |
| ORD ID | ord-52a3b52111b14ee18f21bde286660be6 |
| Source note | uspto-grants-2011_04 |