Hydrochloric Acid → HCID 67102519, compound

Participants

Reaction Steps

To a solution of (R)-tert-butyl 3-(2-((6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinamido)methyl)-5-oxopyrrolidin-1-yl)propylcarbamate (72 mg, 0.12 mmol) in MeOH (5.0 mL) was added HCl (1.0 mL, 4 mmol, 4 M in dioxane). The reaction mixture was stirred at r.t. for 2 h. LC/MS indicated the reaction was complete. The reaction mixture was concentrated under reduced pressure to give (R)—N-((1-(3-aminopropyl)-5-oxopyrrolidin-2-yl)methyl)-6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinamide hydrogen chloride (75 mg, quantitative). LRMS (M+H+) m/z 515.1.

Provenance & Evidence