1,3-Propanediamine → HCID 23729154, compound

Participants

Reaction Steps

A solution of N-((6-bromopyridin-2-yl)methyl)-6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinamide (50 mg, 0.095 mmol) and propane-1,3-diamine (396 ul, 4.75 mmol) in NMP was stirred in microwave at 15° C. for 15 min. The reaction mixture was purified on RP-HPLC using a mixture of acetonitrile and H2O gave N-((6-(3-aminopropylamino)pyridin-2-yl)methyl)-6-(2-cyanophenyl)-2-(3-fluorophenethylamino)nicotinamide (28 mg, 56%). LRMS (M+H+) m/z 524.1.

Provenance & Evidence