1-Hydroxybenzotriazole → HCID 57542468, compound

Participants

Reaction Steps

To a mixture of 2-(3-fluorophenethylamino)-6-(1H-pyrazol-4-yl)nicotinic acid (prepared according to example 1, method A) (1.0 g, 3.07 mmol) in DMF (10 mL) was added HBTU (1.75 g, 4.6 mmol), HOBt (0.62 g, 4.6 mmol), then amine 7 (0.66 g, 6.13 mmol). The reaction mixture was stirred at room temperature for 2 hr. The crude mixture was purified on RP-HPLC using a mixture of acetonitrile and H2O to give 2-(3-fluorophenethylamino)-6-(1H-pyrazol-4-yl)-N-(pyridin-3-ylmethyl)nicotinamide as a pale yellow solid (0.79 g, 62%). LRMS (M+H+) m/z 417.1.

Provenance & Evidence