HCID 57730432, compound → HCID 11528121, compound

Participants

Reaction Steps

To a solution of phenylmethyl (2S)-4-[(2′-fluoro-5′-{[({3-[(1-methyl-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl)-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate (120 mg, 0.18 mmol) in 5 mL of MeOH, was added 10% Pd/C (60 mg). The mixture was hydrogenated using a hydrogen balloon for 12 hours. After flittering off the catalyst, the mixture was concentrated and the residue was purified by Gilson reverse phase HPLC, eluting with acetonitrile/water/0.1% TFA (10/90 to 70/30, v/v, over 12 min), to give the title compound (65 mg, 41%). LC/MS: m/z, 529 (M+H), 1.29 min.

Provenance & Evidence