Sodium hydride → HCID 11685871, compound

Participants

Reaction Steps

Following the general procedure outlined in Example 66, 1,1-dimethylethyl (2S)-4-[(5′-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2′-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate (47.3 mg, 0.0662 mmol), NaH (6.62 mg, 0.262 mmol) and (bromomethyl)cyclohexane (0.0150 mL, 0.108 mmol) in DMF (1.0 mL) were reacted to give the desired product (7.9 mg, 19.6%). EI-MS m/z 611 (M−H)+.

Provenance & Evidence