Sodium hydride → HCID 11685575, compound

Participants

Reaction Steps

Following the general procedure outlined in Example 66, 1,1-dimethylethyl (2S)-4-[(5′-{[({3-[(1-{[(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2′-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate (76.1 mg, 0.106 mmol), NaH (8.29 mg, 0.345 mmol) and (bromomethyl)cyclopropane (0.0155 mL, 0.160 mmol) in DMF (1.0 mL) were reacted to give the desired product (8.4 mg, 13.7%). EI-MS m/z 569(M−H)+.

Provenance & Evidence