Sodium hydride → HCID 11692684, compound

Participants

Reaction Steps

Following the general procedure outlined in Example 66, 1,1-dimethylethyl (2S)-4-[(5′-{[({3-[(1-([(1,1-dimethylethyl)oxy]carbonyl}-4-piperidinyl)methyl]phenyl}carbonyl)amino]methyl}-2′-fluoro-3-biphenylyl)methyl]-2-methyl-1-piperazinecarboxylate (76.1 mg, 0.106 mmol), NaH (8.29 mg, 0.345 mmol) and 2-bromoethyl methyl ether (0.015 mL, 0.160 mmol) in DMF (1.0 mL) were reacted to give the desired product (16.6 mg, 27.2%). EI-MS m/z 573(M−H)+.

Provenance & Evidence