HCID 67101589, compound → HCID 23114666, compound

Participants

Reaction Steps

Methyl 3-[6-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-3-yl]acrylate (160 mg, 0.34 mmol) was dissolved in ethanol (15 ml). To the resulting solution was added palladium carbon (30 mg). The resulting mixture was vigorously stirred under a hydrogen atmosphere of 1 atmospheric pressure for 24 hours. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure. The residue thus obtained was purified by silica gel chromatography (hexane:ethyl acetate=5:1) to give the title compound (94 mg, 58%) as needle crystals.

Provenance & Evidence