Lithium Hydroxide → HCID 23114798, compound

Participants

Reaction Steps

In tetrahydrofuran (5 ml) was dissolved methyl 3-[6-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-3-yl]propionate (92 mg, 0.20 mmol). An aqueous solution (3 ml) of lithium hydroxide (23 mg, 0.5 mmol) was added to the resulting solution and the mixture was stirred for 2 hours. After addition of 10% sodium hydrogensulfate, the resulting mixture was extracted with ethyl acetate. The extract was washed with water and brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give a residue. The resulting residue was crystallized from ethanol to give the title compound (67 mg, 75%) as needle crystals.

Provenance & Evidence