Dichloromethane → HCID 23114554, compound

Participants

Reaction Steps

To methylene chloride (20 ml) of the 4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridine (221 mg, 0.58 mmol) obtained in Example 20 was added 3-chloroperbenzoic acid (100 mg, 0.58 mmol). The resulting mixture was stirred for 20 hours. The reaction mixture was diluted with ether (60 ml). The diluted mixture was washed with a saturated aqueous solution of sodium bicarbonate, water and brine, dried and then filtered. The filtrate was concentrated under reduced pressure to afford a residue. The resulting residue was subjected to silica gel chromatography (ethyl acetate) to give the title compound (183 mg, 80%). The compound was crystallized from ethanol to afford colorless needle crystals.

Provenance & Evidence