Potassium Carbonate → HCID 23114812, compound

Participants

Reaction Conditions

Reaction Steps

The 4-[2-[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-2-yl]aminoethyl]morpholine-N-oxide (78 mg, 0.14 mmol) obtained in Example 61 was dissolved in a mixed solvent of acetic acid (2.0 ml) and water (2.0 ml). The resulting solution was heated to 60° C. and iron powder (40 mg, 0.72 mmol) was added thereto. The resulting mixture was stirred for 30 minutes. After cooling, the reaction mixture was poured into a saturated aqueous solution of potassium carbonate, followed by extraction with ethyl acetate (60 ml). The extract was washed with brine, dried and concentrated under reduced pressure. The residue thus obtained was purified by silica gel chromatography (3% methanol/chloroform solution) to give the title compound (30 mg, 40%).

Provenance & Evidence