Trifluoroacetic acid → HCID 23114615, compound

Participants

Reaction Steps

In methylene chloride (2.0 ml) was dissolved t-butyl 2-[N-[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-2-yl]-N-methylamino]ethylmethylcarbamate (61 mg, 0.10 mmol). To the resulting solution were added anisole (40 μl) and trifluoroacetic acid (200 μl) at room temperature and the resulting mixture was stirred for 1 hour. The residue obtained by concentrating the reaction mixture under reduced pressure was purified by silica gel chromatography (3% methanol/chloroform 3%→methanol, 3% t-butylamine/chloroform) to give the title compound (21 mg, 41%) as an oil.

Provenance & Evidence