Hydrochloric Acid → HCID 23114614, compound

Participants

Reaction Steps

A tetrahydrofuran solution (5 ml) of the methyl(E)-3-[6-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]pyridin-3-yl]acrylate (460 mg, 0.991 mmol) obtained in Example 44 was added a 1N sodium hydroxide solution (3.0 ml). The resulting mixture was stirred at room temperature for 4 hours. The reaction mixture was acidified with 1N hydrochloric acid, followed by extraction with ethyl acetate. The extract was washed with water and brine, dried over magnesium sulfate and concentrated. The crude title compound was obtained at a stoichiometric ratio. A portion of the resulting solid was recrystallized from ethyl acetate-hexane to give the title compound (29.4 mg, 0.0653 mmol) as a colorless solid.

Provenance & Evidence