Hexane → HCID 23114787, compound

Participants

Reaction Steps

To a mixed solution of (E)-2-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]-6-(2-pyridin-2-ylvinyl)pyridine (180 mg, 0.373 mmol) in ethanol (5 ml) and 1,4-dioxane (2 ml) was added an ethanol suspension (1 ml) of Raney nickel. Under a hydrogen atmosphere of 1 atmospheric pressure, the resulting mixture was vigorously stirred for 1.5 hours. After filtration of the reaction mixture, the filtrate was concentrated under reduced pressure. The residue thus obtained was subjected to flash silica gel column chromatography. The fraction obtained from the hexane:ethyl acetate=3:2 eluate was concentrated under reduced pressure, followed by recrystallization from hexane:ethyl acetate to give the title compound (110 mg, 0.227 mmol, 61%) as a white powder.

Provenance & Evidence