1,4-Dioxane → HCID 23114785, compound

Participants

Reaction Steps

A 1,4-dioxane (2.0 ml) solution of the 2,5-dichloro-4-[(4-chlorophenylthio)-(2,5-difluorophenyl)methyl]pyridine (200 mg, 0.48 mmol) obtained in Example 54 and methylaminoethanol (200 μl) was stirred at 110° C. for 3 days under an argon atmosphere. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue thus obtained was purified by silica gel chromatography (hexane:ethyl acetate=3:1) to give the title compound (164 mg, 75%) as an oil.

Provenance & Evidence