Hydrochloride methanol → HCID 23114863, compound

HRID 2080457Notes

Reaction equation

HRID 2080457 reaction equation
[Cl:1][C:2]1[C:3]([CH:22]([S:31]([C:34]2[CH:39]=[CH:38][C:37]([Cl:40])=[CH:36][CH:35]=2)(=[O:33])=[O:32])[C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[F:30])=[CH:4][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[N:6][CH:7]=1.[ClH:41].CO>C(Cl)(Cl)Cl>[ClH:1].[ClH:41].[Cl:1][C:2]1[C:3]([CH:22]([S:31]([C:34]2[CH:35]=[CH:36][C:37]([Cl:40])=[CH:38][CH:39]=2)(=[O:32])=[O:33])[C:23]2[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=2[F:30])=[CH:4][C:5]([NH:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 23114588HCID 23114588, compound

Product 1

HCID 23114863HCID 23114863, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To t-butyl 4-[[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]piperidine-1-carboxylate (41 mg, 0.067 mmol) was added a 20% hydrochloric acid-methanol solution. The resulting mixture was stirred for 2 hours. The reaction mixture was concentrated under reduced pressure. The residue thus obtained was dissolved in chloroform, followed by further concentration. The amorphous substance thus obtained was dried under reduced pressure to afford the title compound (34 mg, 84%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe residue thus obtained
  3. concentrationfollowed by further concentration
  4. customThe amorphous substance thus obtained
  5. customwas dried under reduced pressure

Sources & evidence

ORD record
ord-90b18853ade04ad2a291672909c7216a
Source dataset
uspto-grants-2011_04
Patent number
US07932271B2

Reaction notes

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