Ethanolamine → HCID 23114716, compound

HRID 2080461Notes

Reaction equation

HRID 2080461 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH:8]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[F:24])[S:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)[C:5]([Cl:25])=[CH:4][N:3]=1.[NH2:26][CH2:27][CH2:28][OH:29]>O1CCOCC1>[Cl:25][C:5]1[C:6]([CH:8]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[F:24])[S:9][C:10]2[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=2)=[CH:7][C:2]([NH:26][CH2:27][CH2:28][OH:29])=[N:3][CH:4]=1

Participants

4

Reactant 2

HCID 700EthanolamineHCID 23114752HCID 23114752, compound

Product 1

HCID 23114716HCID 23114716, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A 1,4-dioxane (1.5 ml) solution of 2,5-dichloro-4-[(2,5-difluorophenyl)-(4-fluorophenylthio)methyl]pyridine (200 mg, 0.50 mmol) and 2-aminoethanol (300 μl) was stirred at 120° C. for 2 days under an argon atmosphere. After cooling to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to give the title compound (120 mg, 56%) as an oil.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customThe residue was purified by silica gel chromatography (hexane:ethyl acetate=1:1)

Sources & evidence

ORD record
ord-e2cebb2994834f5898d7394e12f277e2
Source dataset
uspto-grants-2011_04
Patent number
US07932271B2

Reaction notes

Loading…