Hydrochloride methanol → HCID 23114600, compound

HRID 2080469Notes

Reaction equation

HRID 2080469 reaction equation
[Cl:1][C:2]1[C:3]([CH:19]([S:28]([C:31]2[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[CH:4][C:5]([NH:8][CH2:9][CH2:10][NH:11]C(=O)OC(C)(C)C)=[N:6][CH:7]=1.[ClH:38].CO>>[ClH:1].[ClH:38].[Cl:1][C:2]1[C:3]([CH:19]([S:28]([C:31]2[CH:32]=[CH:33][C:34]([Cl:37])=[CH:35][CH:36]=2)(=[O:30])=[O:29])[C:20]2[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=2[F:27])=[CH:4][C:5]([NH:8][CH2:9][CH2:10][NH2:11])=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 21893726Hydrochloride methanolHCID 23114740HCID 23114740, compound

Product 1

HCID 23114600HCID 23114600, compoundYield 76%

Procedure

To t-butyl 2-[[5-chloro-4-[(4-chlorophenylsulfonyl)-(2,5-difluorophenyl)methyl]pyridin-2-yl]amino]ethylcarbamate (146 mg, 0.25 mmol) was added a 20% hydrochloric acid-methanol solution (1 ml). The resulting mixture was stirred for 1 hour. The residue obtained by concentrating the reaction mixture under reduced pressure was crystallized from ethanol to give the title compound (106 mg, 76%).

Workup

  1. customThe residue obtained
  2. concentrationby concentrating the reaction mixture under reduced pressure
  3. customwas crystallized from ethanol

Sources & evidence

ORD record
ord-61b9d64190cb4131baf945c76c0c5742
Source dataset
uspto-grants-2011_04
Patent number
US07932271B2

Reaction notes

Loading…