tert-Butanol → HCID 58734256, compound

Participants

Reaction Steps

Under an argon atmosphere, diphenylphosphoryl azide (2.9 ml, 13.6 mmol) and triethylamine (2.7 ml, 19.4 mmol) were added to a solution of 4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]-5-methylpicolinic acid (2.8 mg, 6.40 mmol) in a mixture of t-butanol (20 ml) and toluene (40 ml). The resulting mixture was stirred for 16 hours under heating and refluxing. After cooling, ethyl acetate was added to the reaction mixture. The resulting mixture was washed sequentially with a saturated aqueous solution of sodium bicarbonate and brine. The organic layer thus obtained was dried over magnesium sulfate, and concentrated under reduced pressure. The residue thus obtained was washed sequentially with hexane and ethyl acetate to give the title compound (2.60 g, 5.11 mmol, 80%) as a white powder.

Provenance & Evidence