Tetrabutylammonium Fluoride → HCID 23114784, compound

Participants

Reaction Steps

After N-[5-chloro-4-[(4-chlorophenylsulfonyl)(5-cyano-2-fluorophenyl)methyl]pyridin-2-yl]-N-(methylsulfonyl)methanesulfonamide (80 mg, 0.11 mmol) was dissolved in tetrahydrofuran (3 ml), a tetrahydrofuran solution (1.0M, 0.15 ml, 0.15 mmol) of tetrabutylammonium fluoride was added to the resulting solution at 0° C. The resulting mixture was stirred at room temperature for 1 hour. The residue obtained by concentrating the reaction mixture under reduced pressure was subjected to silica gel chromatography. The fraction obtained from the n-hexane:ethyl acetate=2:1 eluate was concentrated under reduced pressure to afford a white solid. The resulting white solid was washed with ether to give the title compound (32 mg, 0.06 mmol, 46%) as a white powder.

Provenance & Evidence