HCID 58734272, compound → HCID 23114628, compound

Participants

Reaction Steps

A Raney nickel suspension (“R-100”, product of Nikko Rika Corporation) was washed sequentially with water and ethanol to give a corresponding ethanol suspension. The resulting ethanol suspension (1 ml) was added to a solution of methyl(E)-3-[4-[(4-chlorophenylsulfonyl)(2,5-difluorophenyl)methyl]-5-fluoropyridin-2-yl]acrylate (290 mg, 0.602 mmol) in a mixture of ethanol (6 ml) and 1,4-dioxane (4 ml). The resulting mixture was stirred vigorously for 30 minutes under a hydrogen atmosphere of 1 atmospheric pressure. The reaction mixture was filtered, followed by concentration under reduced pressure. The residue thus obtained was dissolved in dichloromethane. The resulting solution was dried over magnesium sulfate and concentrated under reduced pressure. The residue thus obtained was washed with hexane to give the title compound (252 mg, 0.521 mmol, 87%) as a white powder.

Provenance & Evidence