Hydrogen Peroxide → HCID 23114649, compound

Participants

Reaction Steps

To a methanol (5 ml) solution of [5-chloro-4-[(4-chlorophenylthio)(2,5-difluorophenyl)methyl]pyridin-2-yl]methanol (130 mg, 0.315 mmol) were added hexaammonium heptamolybdate tetrahydrate (20 mg) and 30% aqueous hydrogen peroxide (3 ml). The resulting mixture was stirred for 6 hours. After water was added to the reaction mixture, the resulting mixture was extracted with ethyl acetate. The extract was washed sequentially with water, a saturated aqueous solution of sodium bicarbonate, a saturated aqueous solution of sodium thiosulfate and brine. The organic layer thus obtained was dried over magnesium sulfate, and concentrated under reduced pressure. The residue thus obtained was subjected to flash silica gel column chromatography. The fraction obtained from the hexane:ethyl acetate=2:1 eluate was concentrated under reduced pressure. The residue was recrystallized from hexane:ethyl acetate to give the title compound (101 mg, 0.227 mmol, 72%) as a white powder.

Provenance & Evidence